Unlocking New Insights in Tissue Microenvironments

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Our Capabilities

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Technology Highlights

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Overview

Unlocking New Insights in Tissue Microenvironments

Understanding the intricate behavior of individual cells is critical in today’s biomedical research, especially for immune system analysis, disease progression, and therapeutic response.

Imaging Mass Cytometry™ (IMC™)

The dynamics of tissue microenvironments play a crucial role in understanding disease progression, therapeutic response, and biomarker discovery. Imaging Mass Cytometry™ (IMC™) technology, powered by the Hyperion™ XTi Imaging System, enables researchers to explore the complexity of these dynamics with unparalleled precision. By detecting over 40 protein and RNA markers simultaneously in tissue samples, IMC uncovers spatial relationships that conventional imaging methods overlook.

Discover the throughput and precision that is uniquely designed for translational researchers.

Capabilities

Unparalleled Multiplexing Capability

Understanding the intricate behavior of individual cells is critical in today’s biomedical research, especially for immune system analysis, disease progression, and therapeutic response.

High Dynamic Range

Unlike traditional fluorescence-based imaging techniques, which often struggle with signal saturation and autofluorescence, IMC captures both high and low levels of protein expression in the same sample with exceptional clarity.

Assay development time

Because IMC technology uses an antibody reagent cocktail, it is simple to mix and match different antibodies without extensive assay validation.

Simultaneous Detection of 40+ Markers

Identify therapeutic targets that may be relevant to developing treatment strat…

Flexibility of tissue acquisition

With the Hyperion XTi™ Slide Loader, researchers can image up to 40 slides in 24 hours, making it easier to process large-scale studies and accelerate results without compromising precision – run an entire study in an automated, walkaway run.

No Autofluorescence Interference

IMC utilizes metal-tagged antibodies instead of fluorophores, eliminating issues with autofluorescence and delivering cleaner, more reliable data, even from challenging tissue samples.

Fluorescence-Based Imaging

Traditional

Traditional imaging methods, such as cyclic immunofluorescence, are limited by their low dynamic range, autofluorescence interference, and slow, multi-cycle processes. For example, brightfield imaging (DAB) gives at best one order of magnitude (OoM) of dynamic range, while fluorescence gives 2–3 OoM and IMC gives 5 OoM.

Our Solution

Fluorescence-Based Imaging

Standard Biotools

IMC overcomes these challenges by capturing the full dynamic range of spatial biomarkers, detecting both high- and low-expressing proteins simultaneously. This approach eliminates the need for multiple imaging cycles and delivers high-resolution, quantitative data without the drawbacks of autofluorescence. IMC provides up to 100 times higher throughput than cyclic fluorescence, making it the ideal solution for large-scale research studies.

Staining Redundancy

< 20 Markers

Spectral Overlap

Fluorescence-Based Imaging

Traditional

Our Solution

Fluorescence-Based Imaging

Standard Biotools

Staining Redundancy

< 20 Markers

Spectral Overlap

Technology

Imaging Mass Cytometry Technology

Imaging Mass Cytometry™ (IMC™) is the most trusted technology that enables researchers to accurately assess complex phenotypes and immune spatial interactions in the tissue microenvironment.

Hyperion XTi

CyTOF XT detects over 50 markers at once, far exceeding the limits of traditional flow cytometry. This enables a comprehensive analysis of immune populations and functional responses in a single experiment.